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The Change
Maceňková, Katarína ; Fexová, Patricie (referee) ; Artamonov, Vasil (advisor)
In work entitled CHANGE, I return in my memories to my home region, a town where I have lived and lived most of my life and which has been nicknamed the "Triangle of Death" for decades. This time period has had and continues to have a significant impact on my existence. In the first phase of the timeline of creating the topic of the diploma thesis, are my returns through induction and deduction. I approach my father's illness, which is not uncommon in my homeland. I connect connections leading to finding out the causes of origin and occurrence. Subsequently, I recall memories related to the stories heard from people about the factory, which was supposed to be and perhaps was the livelihood for the inhabitants of the poor eastern Slovakia, as well as the production of PCBs. I create, compile and depict images hidden in the memory of moments from my lived childhood. I depict the Chemko Strážske factory, which at that time was a kind of illusion of a happy life. I am looking for a way of acceptance and ways of reconciliation using painting techniques, through the representation of symbols and the central characters that represent it all.
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The Impact of Selected Endocrine Disruptors on Human Spermatogenesis
Vítků, Jana ; Hill, Martin (advisor) ; Pohanka, Michal (referee) ; Lapčík, Oldřich (referee)
Steroid hormones in testis play an important role in spermatogenesis, maintenance of the male reproductive tract, production of semen and the maintenance of secondary sex characteristics and libido. They are also discussed as a target for substances called endocrine disruptors (EDs). No complex study was conducted on evaluation of relationships between EDs and steroid spectrum in 2 biological fluids; seminal plasma and plasma. The aim of the PhD. thesis was to develop and validate a method for determination of bisphenol A (BPA) and steroid spectrum in plasma and seminal plasma and to shed more light into mechanisms of ED action and effects of BPA and polychlorinated biphenyls (PCBs) on human spermatogenesis and steroidogenesis. Two new liquid-chromatography mass spectrometry methods for determination of BPA and 11 steroids in plasma and seminal plasma were developed and validated. The methods were used for estimation of analyte concentrations in 191 men with a different degree of fertility. Concurrently, the levels of six congeners of PCBs, gonadotropins, selenium and zinc in plasma were estimated. Partial correlations adjusted for age and BMI were calculated to evaluate relationships between these analytes. Seminal BPA, but not plasma BPA, was negatively associated with sperm concentration...
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The Impact of Selected Endocrine Disruptors on Human Spermatogenesis
Vítků, Jana
Steroid hormones in testis play an important role in spermatogenesis, maintenance of the male reproductive tract, production of semen and the maintenance of secondary sex characteristics and libido. They are also discussed as a target for substances called endocrine disruptors (EDs). No complex study was conducted on evaluation of relationships between EDs and steroid spectrum in 2 biological fluids; seminal plasma and plasma. The aim of the PhD. thesis was to develop and validate a method for determination of bisphenol A (BPA) and steroid spectrum in plasma and seminal plasma and to shed more light into mechanisms of ED action and effects of BPA and polychlorinated biphenyls (PCBs) on human spermatogenesis and steroidogenesis. Two new liquid-chromatography mass spectrometry methods for determination of BPA and 11 steroids in plasma and seminal plasma were developed and validated. The methods were used for estimation of analyte concentrations in 191 men with a different degree of fertility. Concurrently, the levels of six congeners of PCBs, gonadotropins, selenium and zinc in plasma were estimated. Partial correlations adjusted for age and BMI were calculated to evaluate relationships between these analytes. Seminal BPA, but not plasma BPA, was negatively associated with sperm concentration...
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The Change
Maceňková, Katarína ; Fexová, Patricie (referee) ; Artamonov, Vasil (advisor)
In work entitled CHANGE, I return in my memories to my home region, a town where I have lived and lived most of my life and which has been nicknamed the "Triangle of Death" for decades. This time period has had and continues to have a significant impact on my existence. In the first phase of the timeline of creating the topic of the diploma thesis, are my returns through induction and deduction. I approach my father's illness, which is not uncommon in my homeland. I connect connections leading to finding out the causes of origin and occurrence. Subsequently, I recall memories related to the stories heard from people about the factory, which was supposed to be and perhaps was the livelihood for the inhabitants of the poor eastern Slovakia, as well as the production of PCBs. I create, compile and depict images hidden in the memory of moments from my lived childhood. I depict the Chemko Strážske factory, which at that time was a kind of illusion of a happy life. I am looking for a way of acceptance and ways of reconciliation using painting techniques, through the representation of symbols and the central characters that represent it all.
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The Impact of Selected Endocrine Disruptors on Human Spermatogenesis
Vítků, Jana
Steroid hormones in testis play an important role in spermatogenesis, maintenance of the male reproductive tract, production of semen and the maintenance of secondary sex characteristics and libido. They are also discussed as a target for substances called endocrine disruptors (EDs). No complex study was conducted on evaluation of relationships between EDs and steroid spectrum in 2 biological fluids; seminal plasma and plasma. The aim of the PhD. thesis was to develop and validate a method for determination of bisphenol A (BPA) and steroid spectrum in plasma and seminal plasma and to shed more light into mechanisms of ED action and effects of BPA and polychlorinated biphenyls (PCBs) on human spermatogenesis and steroidogenesis. Two new liquid-chromatography mass spectrometry methods for determination of BPA and 11 steroids in plasma and seminal plasma were developed and validated. The methods were used for estimation of analyte concentrations in 191 men with a different degree of fertility. Concurrently, the levels of six congeners of PCBs, gonadotropins, selenium and zinc in plasma were estimated. Partial correlations adjusted for age and BMI were calculated to evaluate relationships between these analytes. Seminal BPA, but not plasma BPA, was negatively associated with sperm concentration...
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The Impact of Selected Endocrine Disruptors on Human Spermatogenesis
Vítků, Jana ; Hill, Martin (advisor) ; Pohanka, Michal (referee) ; Lapčík, Oldřich (referee)
Steroid hormones in testis play an important role in spermatogenesis, maintenance of the male reproductive tract, production of semen and the maintenance of secondary sex characteristics and libido. They are also discussed as a target for substances called endocrine disruptors (EDs). No complex study was conducted on evaluation of relationships between EDs and steroid spectrum in 2 biological fluids; seminal plasma and plasma. The aim of the PhD. thesis was to develop and validate a method for determination of bisphenol A (BPA) and steroid spectrum in plasma and seminal plasma and to shed more light into mechanisms of ED action and effects of BPA and polychlorinated biphenyls (PCBs) on human spermatogenesis and steroidogenesis. Two new liquid-chromatography mass spectrometry methods for determination of BPA and 11 steroids in plasma and seminal plasma were developed and validated. The methods were used for estimation of analyte concentrations in 191 men with a different degree of fertility. Concurrently, the levels of six congeners of PCBs, gonadotropins, selenium and zinc in plasma were estimated. Partial correlations adjusted for age and BMI were calculated to evaluate relationships between these analytes. Seminal BPA, but not plasma BPA, was negatively associated with sperm concentration...
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Hodnocení stavu životního prostředí: Monitoring cizorodých látek v potravních řetězcích: Hodnocení ekologických rizik vyplývajících z dat projektu, návrh následných opatření
TOCOEN, Brno ; Volka, Karel ; Holoubek, Ivan
Na 22 lokalitách byly monitorovány hodnoty kontaminace těžkými kovy (kadmium, olovo, rtuť, zinek, měď, nikl, arsen), polychlorovanými bifenyly, organochlorovými pesticidy a polyaromatickými uhlovodíky. Jsou navrhována koncepční řešení pro zajištění soustavného, kvalitního a vypovídajícího monitoringu pro hodnocení kvality životního prostředí . Zpráva obsahuje podrobné výsledky měření a přináší jejich interpretaci ve studii Stupeň kontaminace různých matric jednotlivými polutanty - hodnoceno s ohledem na časový vývoj (1996-2000) a rozdíly mezi vzorkovanými lokalitami.
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Hodnocení stavu životního prostředí: Monitoring cizorodých látek v potravních řetězcích
Vysoká škola chemicko-technologická v Praze, Praha ; Suchánek, Miloslav ; Volka, Karel
Studie Bioindikátory - Zhodnocení zátěže životního prostředí pomocí nálezů polychlorovaných bifenylů (PCB) a organochlorových pesticidů (OCP) ve tkáních zajíce polního (Lepus europaeus) a prasete divokého (Sus scrofa) ve vybraných lokalitách ČR. Kontaminace organismu býložravců odráží především plošnou imisní zátěž vegetace vyplývající z dálkového transportu. Zvýšené hladiny sledovaných perzistentních škodlivin indikují přítomnost lokálního zdroje kontaminace. Jsou uvedeny výsledky analýzy vzorků. Studie Suchánek - Bukovjan: Interpretace vzorkovacího pokusu s živými biomarkery za období 1996 -2000 dokazuje, že zdravotní stav živočišných bioindikátorů vzájemně koreluje s koncentrací chemických prvků včetně skupiny rizikových (Pb, Hg, Cd).
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